Ability of vasoconstrictor drugs to cause adrenal medullary discharge after "sensitization" by ganglion stimulating agents.
نویسندگان
چکیده
HAAS and Goldblatt 1 reported that infusion of DMPP (l,l-dimethyl~t-phenylpiperazinium iodide), a ganglion stimulating agent, causes increase of pressor responsiveness to angiotensin. The experiments reported here reveal that, instead of enhancement of the direct effect of angiotensin on the cardiovascular S3'Stem, the larger responses that follow treatment with DMPP are due to adrenal discharge of pressor material that is presumably composed of catechol amines. Other ganglion stimulating agents "sensitize" the adrenal in the same manner, and a variety of vasoconstrictor drags elicit discharge from the sensitized gland.
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ورودعنوان ژورنال:
- Circulation research
دوره 9 شماره
صفحات -
تاریخ انتشار 1961